Can Shiseido Ultimune Power Infusing Serum Be the Future of Anti-Ageing Skincare?
One thing is certain when Shiseido launches a product: you can expect cutting-edge technology, advanced skincare science, exclusive (often patented) ingredients, and impressive clinical results. And when a single serum has been awarded 269 beauty awards worldwide, it’s clear this is a true hero product that deserves closer inspection.
Shiseido is renowned for its groundbreaking research, and in March 2025 the brand revealed new findings in the fight to slow the skin’s ageing cycle. Backed by over 30 years of scientific research, Ultimune Power Infusing Serum is positioned as the ultimate defence against aged cells, the root cause of many visible signs of ageing.
Originally launched a decade ago, Ultimune is now in its 4th edition. With one bottle sold every 17 seconds globally, it has become a cult favourite. The latest formula introduces Power Fermented Camellia+, a patented innovation designed to reignite skin’s regenerative power and “infuse 30 million skin cells with new life.”
The Science Behind the Formula
The skin has its own inner defence system, and supporting this system is key to slowing the ageing process. Shiseido’s Power Fermented Camellia+ has been developed to strengthen this defence and trigger the skin’s natural regenerative power.
As our cells age, they send out negative signals that accelerate ageing in surrounding healthy cells. Ideally, the skin would remove these aged cells on its own, but Shiseido’s research discovered the role of Memory T Cells, immune cells that have the remarkable ability to quickly distinguish between aged and healthy cells. Because Memory T Cells can “memorise” these features, they precisely target and eliminate aged cells.
The higher the number of Memory T Cells, the fewer aged cells remain, leading to healthier regeneration and a slowdown in the skin’s ageing cycle. This is groundbreaking research, and Shiseido appears to be the first brand able to claim that Memory T Cells can help eliminate the root cause of skin ageing, aged cells themselves.
Shiseido’s Power Fermented Camellia+ works by boosting Memory T Cells in the skin. The higher the number of Memory T Cells, the fewer aged cells remain, allowing healthy cells to thrive and regenerate. This breakthrough technology ensures visible results: enhanced radiance, smoother texture, reduced fine lines and wrinkles, improved skin tone, and increased firmness and elasticity.
This innovation is backed by over 30 years of research and developed in collaboration with Harvard University, forming the scientific foundation for what Shiseido hopes will help prevent future skin concerns at their root.
The science behind the anti-stress combination of rose and lotus has been shown to lower cortisol, the primary female stress hormone. This is remarkable, given how huge the impact cortisol has on both the body and the skin. Incorporating aromacology, which is the use of scent to influence mind and body, helps reduce the effects of stress on our skin and overall well-being, is so clever.
The Hero Ingredient: Power Fermented Camellia+
At the heart of the formula is Power Fermented Camellia+, Shiseido’s patented and exclusive technology. This ingredient is enhanced through a bio-fermentation process with Ki-koji, which boosts potency by enriching the concentration of 14 types of amino acids, making the complex 3.4 times richer than before. The fermented camellia seed extract is the power behind the Memory T cell boosting powers.
The camellia flower itself is renowned as one of nature’s most resilient blooms. Shiseido sources camellia from the Goto Islands of Nagasaki, Japan, where the flower thrives in a harsh environment, yet continues to bloom and regenerate year after year.
Every part of the camellia plant is used, ensuring nothing goes to waste:
Camellia Seed Extract delivers powerful antioxidant properties to shield the skin against harmful aggressions.
Camellia Leaf Extract helps support and control the oil levels caused by dryness.
Camellia Flower Extract supports the skin barrier by strengthening the stratum corneum’s resistance.
Camellia Seed Oil provides deep and long-lasting moisture.
The results you can expect:
Shiseido is the first skincare brand to be able to clinically prove it can slow the skin ageing cycle.
Clinically proven to tackle all 7 signs of ageing in just one week is an incredible claim that Shiseido doesn’t make loosely, but just look at these results..
Consumer perception results:
In just 3 days:
98% felt their skin had a healthy glow.
After 4 weeks:
98% felt ageing signs (dryness and wrinkles) were visibly reduced.
97% said their skin looks more youthful.
After using one bottle (Using 50mL of ULTIMUNE bottle for 8 weeks):
99% felt their skin had become resistant to ageing signs (dryness and wrinkles)
98% felt the serum helped their skin deflect ageing from the core.
98% felt the serum would help sustain their beauty for 10years.
Based on consumer sensory tests with 107 women
Clinically proven results (Instrumental and clinical expert scoring on 34 volunteers:
In 8 weeks: +86% elasticity / +51% radiance / -63% roughness / -26% fine lines / +40% skin tone evenness / -22% face wrinkles / +38% firmness
My Personal Results
This was love at first application, instantly hydrating, plumping, and smoothing. Over time, I’ve noticed a real improvement in my skin’s overall condition, including a stronger barrier and better defence thanks to powerful antioxidants. With ingredients like ectoin, vitamin E, and amino acids, my skin feels fully supported and is definitely functioning at its optimum level.
Fine lines and wrinkles appear softer, smoother, and more plumped, leaving my complexion looking healthier and more radiant than ever.
Who is Shiseido Ultimune Power Infusing Serum For?
Think of Ultimune as your skin’s very own security system. Memory T cells act like a home alarm, spotting intruders instantly and triggering a rapid defence. Ultimune strengthens those memory T cells so they can recognise the ‘unwanted guests’ (damaged ageing cells) the moment they show up. Or think of your memory T cells as the SAS of your skin, elite soldiers, trained to identify and eliminate threats with precision. Ultimune boosts their strength, keeping your skin’s defence system sharp, resilient, and always ready for action.
It’s not a serum reserved for one skin type or age group; it’s a universal treatment.
All skin types and all ages – There isn't a skin type that wouldn't benefit from this. Even oily skin benefits, as Ultimune helps regulate excess oil while still delivering deep hydration.
Those noticing early or advanced signs of ageing – From fine lines and wrinkles to loss of firmness, rough texture, dryness, or uneven tone, it works to improve overall skin condition and vitality.
Anyone whose skin feels depleted – If stress, illness, medication, or lifestyle shifts have left your skin feeling neglected or lacklustre, Ultimune delivers a much-needed recharge and boost of vitality.
People exposed to daily aggressors – Modern life bombards skin with pollution, stress, and environmental damage. Ultimune strengthens skin’s natural defences so it stays resilient in the face of these challenges.
Those sensitive to Vitamin C – If your skin can’t tolerate traditional vitamin C formulas, this is a powerful antioxidant alternative, offering protection and radiance without irritation.
In short, Ultimune is for anyone who wants their skin to feel stronger, healthier, and more radiant, whether you’re in your 30s, 40s, 50s, or beyond.
Final Thoughts
I honestly can’t speak highly enough about this serum. The fact that it works quietly behind the scenes, reaching areas of skin that the rest of my products can’t touch, is a huge win. It makes perfect sense and is something I’ve believed for a long time: ageing cells disrupt the healthy ones. Until now, I’d never seen technology that helps support the removal of these damaged cells like this, allowing skin to function at its very best. No other product in my routine targets ageing cells quite like this.
It layers effortlessly, delivers instant hydration, and leaves my skin looking smoother, more radiant, plump, and healthy. I truly can’t imagine my routine without it. Paired with my peptides and retinoids, Ultimune has become my secret weapon for maintaining stronger, healthier, and more youthful skin.
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